Pharmacokinetic properties of radiolabeled mutant Interleukin-2v: a PET imaging study
نویسندگان
چکیده
منابع مشابه
Pharmacokinetic properties of radiolabeled mutant Interleukin-2v: a PET imaging study
Interleukin-2 (IL2) is a cytokine that can stimulate cytotoxic immune cells to attack infected and malignant cells. Unfortunately, IL2 can also cause serious immune-related toxicity. Recently, a mutant of IL2 (IL2v) with abolished CD25 binding, increased plasma half-life and less toxicity was engineered. Unlike wild-type IL2 (wt-IL2), mutant IL2v does not bind to the α-subunit (CD25) of the hig...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2018
ISSN: 1949-2553
DOI: 10.18632/oncotarget.23852